If you have CSF installed as the IDS of choice and you have a SMTP timeout on WebMail when trying to send mail, the problem is probably in the csf.conf setting.
Error:
Connection timed out
Server replied: 110 Can’t open SMTP stream.
Solution:
Modify SMTP_BLOCK=”1″ or even better SMTP_ALLOWLOCAL=”1″ in /etc/csf/csf.conf.